Abstract: Blood banking is the process of collecting, separating and warehousing blood. There are numerous file-based repositories of blood bank management that exist for storing data for blood bank ecosystem such as hospitals and centers. This functions for maintaining the information of donors, availability of blood, and transaction information. Currently, these systems are effort intensive, costly, and failed to achieve efficiency in terms of its filtering mechanism which makes repository penetrating faster and reliable. This paper introduces a new design for blood banking ecosystem with proper filtering solution using frame-based approach. The system has three major features: (1) blood camp setup module, (2) stocks management module which includes the blood donation and blood releasing, and (3) the filtering system module which shows the nearest blood camp with the available blood type based on the patients’ needs. Also, with the use of frame-based approach as filtering method, the system is more efficient and reliable compared to other blood banking repository systems. The system’s functionality was tested for its efficiency, usability, and reliability and the results are revealed in the survey. Conclusions and future work were also provided in this paper.