Abstract: Albeit the potent association between nutrition and health has been repeatedly corroborated in the field of nutrition science through evidence-based approaches, the prevalence of inadequate nutrition among Filipino households is still too high. Therefore, the goal of this study was to pinpoint nutrition challenges faced by Filipino young adults and evaluate whether a personalized nutrition knowledge-based system is a potential nutrition intervention tool. A mixed-methods needs analysis approach was operated to arrive at a panoramic profile of a nutrition knowledge-based system through the participation of respondents in an online survey (n = 85) and focus groups (n = 4). The assessment was grounded from the influencing factors of health and nutritional status such as food selection, nutrition barriers, poor eating habits, nutrition knowledge, and with the inclusion of nutrition application for technical feedback. The findings exploited the fact that people do not track what they eat, let alone the nutrients it contained, which eventually leads to undereating or overeating. There was also a commonness in lack of nutrition knowledge to make healthier food choices. Fortunately, the willingness of participants to point their directions towards a healthier lifestyle through the use of a nutrition knowledge-based system was evident. The paper then concluded with recommendations for future studies and how its findings might be utilized for the development of a personalized nutrition system.