Abstract: Serious games offer an innovative blend of entertainment and learning in medical education. This chapter examines the technological underpinnings, challenges, and potential future developments in this domain. Drawing from publications between 2018 and 2023, this systematic review highlights the role of technologies such as web and mobile applications, game engines, augmented reality, virtual reality, mixed reality, and artificial intelligence in personalizing and enhancing the learning experience. However, the use of serious games in medical education also faces several challenges, including the need for adequate technological infrastructure, complex effectiveness assessments, and integration into existing curricula. Moreover, this chapter outlines projections for further research. The authors reveal how serious games have the potential to transform medical education to be more engaging, interactive, and effective, and inspire future research in the development of innovative technologies and learning methods.