Abstract: Primary and backup relays pairs are protection schemes for power systems which are set in conjunction to one another to ensure that the protection system operates by limiting an abnormality within its zone of protection. Breakpoints are the starting points of all assumptions and calculations done in protection systems. Previous methods of determining breakpoints favor linear graph theory and expert theory system rather than machine learning. In this study, an adaptive neuro-fuzzy inference (ANFIS) approach is used to determine the breakpoint set for directional overcurrent relays of a given 3-bus network. The two most influential input variables from 15 inputs affecting breakpoint set are determined by Exhaustive Search. The reduced inputs are then used to design the Sugeno type ANFIS. Experimental results show promising results in terms of Root Mean Square Error.